Uncategorized

Fibronectin unfolded by adherent but not suspended platelets: An in vitro explanation for its dual role in haemostasis

http://repository.vnu.edu.vn/handle/VNU_123/27489

Fibronectin (FN), a dimeric adhesive glycoprotein, which is present both in plasma and the extracellular matrix can interact with platelets and thus contribute to platelet adhesion and aggregation.

It has been shown that FN can decrease platelet aggregation but enhance platelet adhesion, suggesting a dual role of FN in haemostasis.

The prevalent function(s) of FN may be determined by its fibril form. To explore the suggested dual role of this adhesive protein for haemostasis in further detail, we now tested for any differences of adherent and suspended platelets with regard to their effect to unfold and assemble FN upon interaction.

Title:

Fibronectin unfolded by adherent but not suspended platelets: An in vitro explanation for its dual role in haemostasis
Authors: Huynh, Khon
Gyenes, Marianna
Hollenberg, Cornelis P.
Keywords: Fibronectin
platelet adhesion and aggregation
fibronectin assembly
fibronectin unfolding and fibril formation
Issue Date: 2015
Publisher: Đại học Quốc gia Hà Nội
Citation: ISIKNOWLEDGE
Abstract: Fibronectin (FN), a dimeric adhesive glycoprotein, which is present both in plasma and the extracellular matrix can interact with platelets and thus contribute to platelet adhesion and aggregation. It has been shown that FN can decrease platelet aggregation but enhance platelet adhesion, suggesting a dual role of FN in haemostasis. The prevalent function(s) of FN may be determined by its fibril form. To explore the suggested dual role of this adhesive protein for haemostasis in further detail, we now tested for any differences of adherent and suspended platelets with regard to their effect to unfold and assemble FN upon interaction.
Description: THROMBOSIS RESEARCH Volume: 136 Issue: 4 Pages: 803-812 Published: OCT 2015 ; TNS05577
URI: http://repository.vnu.edu.vn/handle/VNU_123/27489
Appears in Collections: Bài báo của ĐHQGHN trong Web of Science

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s