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Systems pharmacology A unified framework for prediction of drug-target interactions

http://repository.vnu.edu.vn/handle/VNU_123/32161

Drug discovery is one important issue in medicine and pharmacology area.

Traditional methods using target-based approach are usually time-consuming and ineffective.

Recently, the problems are approached in a system-level view and therefore it is called systems pharmacology.

This research field deals with the problems in drug discovery by integrating various kinds of biomedical and pharmacological data and using advanced computational methods.

Ultimately, the problems are more effectively solved.

One of the most important problem in systems pharmacology is prediction of drug-target interactions.

Methods: In this review, we are going to summarize various computational methods for this problem. Results: More importantly, we formed a unified framework for the problem.

In addition, to study human health and disease in a more systematically and effectively, we also presented an integrated scheme for a wider problem of prediction of disease-gene-drug associations.

Conclusion: By presenting the unified framework and the integrated scheme, underlying computational methods for problems in systems pharmacology can be understood and complex relationships among diseases, genes and drugs can be identified effectively.

Title: Systems pharmacology A unified framework for prediction of drug-target interactions
Authors: Le, D.-H.
Le, L.
Keywords: Disease-gene association
Drug-disease association
Drug-gene-disease association
Drug-target interaction
Machine learning-based approach
Network-based approach
Issue Date: 2016
Publisher: Bentham Science Publishers B.V.
Citation: Scopus
Abstract: Drug discovery is one important issue in medicine and pharmacology area. Traditional methods using target-based approach are usually time-consuming and ineffective. Recently, the problems are approached in a system-level view and therefore it is called systems pharmacology. This research field deals with the problems in drug discovery by integrating various kinds of biomedical and pharmacological data and using advanced computational methods. Ultimately, the problems are more effectively solved. One of the most important problem in systems pharmacology is prediction of drug-target interactions. Methods: In this review, we are going to summarize various computational methods for this problem. Results: More importantly, we formed a unified framework for the problem. In addition, to study human health and disease in a more systematically and effectively, we also presented an integrated scheme for a wider problem of prediction of disease-gene-drug associations. Conclusion: By presenting the unified framework and the integrated scheme, underlying computational methods for problems in systems pharmacology can be understood and complex relationships among diseases, genes and drugs can be identified effectively.
Description: Current Pharmaceutical Design Volume 22, Issue 23, 1 June 2016, Pages 3569-3575
URI: http://www.eurekaselect.com/141339/article
http://repository.vnu.edu.vn/handle/VNU_123/32161
ISSN: 13816128
Appears in Collections: Bài báo của ĐHQGHN trong Scopus

 

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